Israel targeted Syrian military positions early on Thursday after an unmanned drone entered its airspace from the neighboring country the previous day, the military said.
The military said it struck three Syrian posts "in response to the infiltration of the Syrian UAV," or unmanned aerial vehicle.
Hours earlier, Israel fired a Patriot missile and took down the unmanned drone which had infiltrated its airspace. There were no reports of injuries over the drone's incursion.
That incident came as Prime Minister Benjamin Netanyahu visited Moscow for talks with Vladimir Putin about Syria and Iran.
Russia has been Bashar Assad's key ally in the Syrian civil war.
Israel's main concern is to keep archenemy Iran, also an Assad ally, as far away from its border as possible — along with its proxy, the Lebanese militant group Hezbollah.
Israel has repeatedly said it will not allow Iran to establish a permanent military presence on its doorstep in neighboring Syria.
The military said it will "continue to operate determinedly and decisively against any attempt to breach Israeli sovereignty and will act against any attempt to hurt its civilians.
Last month, Israel fired a missile at a drone that approached its airspace near the Syrian frontier, and in February Israel shot down what it said was an Iranian drone that entered its airspace. It bombed Iranian targets in Syria in response to that incident.