The Germans, with six wins from six games in Group A, face their former coach Berti Vogts as they make the long trip to Azerbaijan for a Euro 2012 qualifier -- probably the last thing they would have wanted at this stage of the campaign.
Germany are the only big guns in action on a night of six less than mouth-watering ties, the others involving teams playing, at best, for second spot in their respective groups.
Bosnia play their first home match since emerging from an international ban when they host Albania, Sweden entertain neighbours Finland and the Faroe Island take on Estonia.
Germany's players scarcely had a rest after the exertions of the World Cup in South Africa last year.
Loew believes they been suffering a knock-on effect ever since and were at "the limit of their strength" after their 2-1 in Austria on Friday