"There is no appetite for that kind of action vis-a-vis Syria," Clinton said, pointing to regional moves by the Arab League and Turkey as key to persuading Syrian President Bashar al-Assad to halt the violence against civilians.
"I believe that what the Arab League does and Turkey says have more affect on the Syrian government and people than the United States, said Clinton."
The United States and the European Union have both imposed a series of targeted sanctions against Damascus. But U.N. sanctions are seen as unlikely given opposition from Russia and China, which last month vetoed a draft Security Council resolution condemning Syria.
The Arab League has suspended Syria and set a Saturday deadline for it to comply with the Arab peace plan, which entails a military pullout from around restive cities and towns, threatening sanctions unless Assad acts to halt the violence.
Clinton told CBS in a separate interview that it was clear Assad's days were numbered.
"Look, Assad's going to be gone; it's just a question of time. What we hope is that they avoid a civil war, that they avoid greater bloodshed, that they make the changes that they should have been making all along. And we think the Arab League pressure is probably the most effective pressure," she said.