The U.S. Federal Bureau of Investigation led a battery of federal, state and local law enforcement agencies on the case, while critically wounded victims of Monday's blasts fought for their lives and others contemplated a new life as amputees.

The bombs ripped through the crowd at the finish line of the Boston Marathon, shattering the annual civic celebration on the Patriots' Day state holiday while tens of thousands of people packed the street to cheer on the runners.

The two devices using gunpowder as the explosive were packed with ball bearings and other shrapnel to maximize injuries, said a senior law enforcement official briefed on the investigation who declined to be identified because of the sensitivity of the information.

No one has been arrested in the bombing. A White House official said the case would be treated as an act of terrorism but it had yet to be determined whether the attack came from a foreign or domestic source. President Barack Obama promised to catch whoever was responsible. "It is a criminal investigation that is a potential terrorist investigation," said Richard DesLauriers, the FBI special agent in charge for Boston.

Many runners were heading for the finish when a fireball and smoke rose from behind cheering spectators and a row of flags representing the countries of participants, video from the scene showed. The two explosions came moments apart some four hours and nine minutes into the race, long after the world-class runners had finished but around the time average contestants were arriving.

'A LOT OF BLOOD'

"I saw people who looked like they had their legs blown off. There was a lot of blood over their legs. Then people were being pushed in wheelchairs," said Joe Anderson, 33, a fisherman from Pembroke, Massachusetts, who had just run the race holding a large U.S. flag.

Many of the victims were gravely injured, Massachusetts Governor Deval Patrick said. Some suffered shrapnel wounds and amputations and will require repeat operations in the coming days, said Peter Fagenholz, a trauma surgeon at Massachusetts General Hospital. Doctors treated 29 patients including eight who were in critical condition, Fagenholz said. Many of the seriously injured patients had suffered bone, soft tissue and vascular damage to their legs, he said. "We're seeing a lot of shrapnel injuries" from small metal debris, Fagenholz told reporters outside the hospital. There had been "several" amputations, he said.

The dead included an 8-year-old boy, the Boston Globe reported, citing two law enforcement sources briefed on the investigation. A 2-year-old with a head injury was being treated at Boston Children's Hospital, the hospital said in a statement.

The blasts put police on alert in major cities across the United States, including in Washington, D.C., and New York City, sites of the Sept. 11 attacks.

The annual Boston Marathon, held since 1897, attracts an estimated half-million spectators and some 20,000 participants every year.