A bomb blast in a Damascus suburb that is home to one of the holiest Shiite shrines in Syria killed eight people on Monday, according to a pro-Assad regime TV station and an activist-run monitoring group.

Syrian state TV said the suicide bomber detonated his explosives-packed vehicle at a military checkpoint at the entrance to the Sayyida Zeinab suburb. Syria's Al-Ikhbariya TV station showed footage of a slight depression on a road near a checkpoint where the bomb was said to have gone off. The wreckage had already been removed.

Al-Manar TV, run by Lebanon's Hezbollah militant group, said eight people were killed in the blast. The Shiite militants have a heavy presence in the suburb. The Syrian Observatory for Human Rights, an activist-run monitoring group, gave the same toll. Syrian state TV said five people were killed and 20 wounded.

The heavily guarded shrine to Sayyida Zeinab, the daughter of the first Shiite imam Ali and granddaughter to the Prophet Muhammad, receives thousands of Shiite pilgrims each year.

Allies of the embattled Bashar Assad regime have mobilized Shiite fighters from Iran, Iraq and Lebanon to fight on the side of regime forces on the grounds of defending the shrine and preserving the country's religious plurality.

A previous bombing in the Sayyida Zeinab suburb, claimed by Daesh terror organization, killed some 130 people in February.

The Syrian uprising began with mostly peaceful protests in 2011, but a brutal government crackdown and the rise of an armed insurgency eventually plunged the country into a full-blown civil war. The fighting has killed more than 250,000 people, according to the United Nations, which stopped tracking casualties several months ago.