At least 40 people were killed and scores injured Saturday in a new wave of regime and Russian airstrikes on the war-battered Aleppo city in northeastern Syria, according to a moderate civil defense official.

Najib al-Ansari said Russian and regime warplanes carried out several raids on moderate-held areas in eastern Aleppo.

"Forty civilians were killed and 180 others injured in the attacks," he told Anadolu Agency.

According to al-Ansari, civil defense teams were struggling to reach the bombed areas to search for survivors under the debris.

On Friday, around 40 people were killed in Russian bombardment of moderate-held areas in Aleppo.

Around 300,000 people live under a crippling siege in eastern Aleppo since September amid relentless airstrikes by regime forces and Russian allies.

On Friday, all hospitals in eastern Aleppo were forced to shut down as a result of the ongoing attacks by regime and Russian forces.

Syria has been locked in a devastating civil war since early 2011.

Since then, hundreds of thousands of people have been killed and millions more displaced by the conflict.