Hat trick hero Cristiano Ronaldo revived Manchester United's hopes of securing a top-4 finish in the Premier League after leading the Red Devils to a 3-2 win over lowly Norwich City.
United's hopes were further boosted when fourth-placed Tottenham Hotspur suffered a surprise 1-0 home defeat to Brighton and Hove Albion, and Arsenal lost at Southampton.
Despite Ronaldo's hat trick, United's win was unconvincing as fan protests against the club's owners returned to Old Trafford.
With the title-chasing top two of Manchester City and Liverpool in FA Cup semifinal duty – with Juergen Klopp's side winning 3-2 at Wembley – the focus in the league turned to the battle for the fourth Champions League spot behind third-placed Chelsea.
The results leave Spurs in fourth, on 57 points from 32 games. Fifth-placed United is level on 54 points with Arsenal, who has a game in hand.
Antonio Conte's Spurs produced a lackluster display and looked set for a frustrating stalemate before Leandro Trossard made things even worse with a 90th-minute winner.
Trossard cut in from the left and beat Hugo Lloris with a low angled shot with the outside of his foot to end the Spurs' run of four straight wins.
Conte was disappointed but said his team needed to embrace the pressure of holding on to the fourth place.
"Now there are six games to go. This race is a big opportunity for us to start to try to cope with the pressure, because when you play without targets ... instead, we deserve to stay in this race and go for a place in the Champions League," he said.
Saints humble Gunners
Arsenal looked to be the favorite for that place at the start of the month but it has now suffered three straight losses with the latest reverse coming against a Southampton side who had been winless in five.
Jan Bednarek got the decisive goal, one minute before halftime after Mohamed Elyounoussi evaded the offside trap and crossed for the defender to finish past goalkeeper Aaron Ramsdale.
Arsenal was on top for large parts of the game but came up against Southampton keeper Fraser Forster in inspired form.
"It’s a really difficult one to take. The way we controlled the game makes it difficult to understand how we lost the game," said Arsenal manager Mikel Arteta.
"We performed but didn’t get a result. We need both. You have to put the ball in the net. You have to make the decisive moments count to win football matches and at the moment we’re not doing that," added the Spaniard.
'Must raise our game'
Cristiano Ronaldo's 50th club career hat trick earned below-par United three vital points.
A first-half double from veteran striker Ronaldo seemingly put the hosts on course for a comfortable win in the sunshine, with Norwich struggling to keep pace.
However, Kieran Dowell's goal out of nowhere in first-half stoppage time got the visiting side back in the contest, before Finnish forward Teemu Pukki completed the Norwich comeback to stun Old Trafford into silence seven minutes after the break.
Fans who protested against the club's owners ahead of the match were singing "you're not fit to wear the shirt" in the second half as their team was second best to a team seven points adrift of the Premier League safety zone.
United's France midfielder Paul Pogba was booed by his own fans as he was substituted before Ronaldo stole the show once again with a superbly taken winner 14 minutes from time.
"The results elsewhere were good. But it doesn't make sense to look to other results. We need to raise our game," said United's interim manager Ralf Rangnick.
19th placed Watford slipped further towards the drop with a 2-1 home defeat to Brentford leaving them on 22 points, six behind 17th placed Everton having played two games more.
Norwich is bottom on 21 points from 32 games while 18th placed Burnley, who sacked manager Sean Dyche on Friday and is on 24 points, play at seventh placed West Ham on Sunday.