On the positive side, France striker Karim Benzema has been in fine form scoring eight goals in pre-season to date.
Barca boss Pep Guardiola, who has three wins and one draw from his four visits to the Bernabeu as coach, has yet to give his only new recruit so far his debut.
Chile forward Alexis Sanchez, along with Argentine Lionel Messi, have only just returned to training after July's Copa America tournament.
Many Barca fans will be hoping the drawn out transfer saga surrounding Arsenal captain Cesc Fabregas will have been concluded by the weekend and that the club's former youth team player will at least be in attendance in the stands.
Barca's pre-season form has been patchy and they often take a while to get into their stride in a season.
"They are always very difficult games and very tense when we play against Real Madrid," Barca forward Pedro told reporters.
"We are starting the season with a difficult test but I'm sure the team will respond."
Guardiola has a number of injury doubts including first-choice defensive partnership Carles Puyol and Gerard Pique, along with Xavi, Maxwell and Ibrahim Afellay.
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