While Group L leaders Villarreal visit Turkish side Osmalıspor, Celta Vigo host Group G leaders Ajax, who are two points above them. Roma veteran Francesco Totti is also eyeing a goal landmark against visiting Austria Vienna in a Group E game featuring the leading sides, both on four points.
Captain Totti, who turned 40 on September 27, could, if he plays, take his goal tally to 100 in UEFA competitions. Roma defender Federico Fazio said: "Getting all three points on Thursday would be huge for our standing in the group and also in terms of our morale. We want to keep on winning and get used to the feeling - it has to become the norm." Fellow Italians Inter Milan badly need a win after two defeats in Group K as they host Premier League side Southampton. "Europe is not simple," Inter coach Frank de Boer said.
"We have to play every game as if it's a derby and so far we haven't done that." Isarael's Hapoel Beer-Sheva, level on four points with Southampton meanwhile greet Sparta Prague, who are a point behind. Of the Spanish contingent, Athletic Bilbao visit Genk in good heart after Sunday's 3-2 defeat of Real Sociedad in the Basque derby. "We are in quite good form and enjoying our games," left-back Mikel Balenziaga said. "But we cannot relax our efforts at all. Thursday's game is important in qualifying for the knockout stage."
Group F is the tightest of all, with Bilbao, Genk, Sassuolo and Rapid Vienna - who host the Italians - all on three points.Germany's Schalke are missing a number of injured players as they visit Russian side Krasnodar in a Group I meeting between two sides who have won their first two games. Fiorentina hope to maintain top spot in Group J in a visit to Slovan Liberec, Bundesliga side Mainz greet Anderlecht in a match between the two top Group C teams, while Group D sees a clash between undefeated Dundalk and Zenit St Petersburg. Among the evening's 24 games, Shakhtar Donetsk are seeking a third win when they greet KAA Gent in Group H.