A new obesity medication not only promotes weight loss but also may help diminish the likelihood of heart disease, according to recent research conducted in the United States.
After a year of taking semaglutide, marketed as Wegovy by Novo Nordisk, patients’ risk of suffering from conditions like a heart attack or a stroke over the next 10 years dropped to 6.3% from 7.6% when measured by a commonly used calculator, researchers at the Mayo Clinic found.
The results, which were presented this week at the European Congress on Obesity in Dublin, are among the first indication that the weight loss induced by the new GLP-1 agonist drugs like Wegovy also brings heart health benefits – something scientists expected but do not yet have much comprehensive data to prove.
The study was only done among 93 patients, and the researchers said that more extensive studies were needed to see if the risk reduction score meant less illness and death long-term.
Novo is expected to release results from its 5-year SELECT trial looking into the health impact of its injectable drug, particularly around heart disease, later this year. Investors, governments and insurers alike are keenly watching the data.
“It is extremely important because we know obesity is a risk factor for cardiovascular disease,” Dr Andres Acosta, one of the researchers, told Reuters.
“So the question is, with 15% (average weight loss) medications, can we start improving cardiovascular risk and say people are dying less?”
The risk was calculated using the American College of Cardiology’s calculator, based on data including blood pressure and cholesterol levels. The team assessed the risk before the patients – mainly white women with a mean BMI of 39.8 but no history of heart disease – started the drug after one year of taking it.
The research was peer-reviewed by the congress organizers, the European Association for the Study of Obesity, but the paper is not yet available. Furthermore, the study was not funded by Novo.
