Neuroscientist Liz Chrastil got the unique chance to see how her brain changed while she was pregnant and share what she learned in a new study that offers the first detailed map of a woman's brain throughout gestation.
Researchers discovered that the transition to motherhood affects nearly every part of the brain.
Although the study looks at only one person, it kicks off a large, international research project that aims to scan the brains of hundreds of women and could one day provide clues about disorders like postpartum depression.
"It’s been a very long journey,” said Chrastil, co-author of the paper published Monday in Nature Neuroscience. "We did 26 scans before, during and after pregnancy” and found "some remarkable things."
More than 80% of the regions studied had reductions in the volume of gray matter, where thinking takes place. This is an average of about 4% of the brain – nearly identical to a reduction that happens during puberty. While less gray matter may sound alarming, researchers said it probably isn't; it likely reflects the fine-tuning of networks of interconnected nerve cells called "neural circuits" to prepare for a new phase of life.
The team began following Chrastil – who works at the University of California, Irvine and was 38 years old at the time – shortly before she became pregnant through in vitro fertilization.
During the pregnancy and for two years after giving birth, they continued performing MRI brain scans and drawing blood to observe how her brain changed with fluctuating hormones. Some of these changes persisted beyond pregnancy.
"Previous studies had taken snapshots of the brain before and after pregnancy, but we’ve never witnessed the brain during this metamorphosis,” said co-author Emily Jacobs of the University of California, Santa Barbara.
Unlike past studies, this one focused on many inner regions of the brain and the cerebral cortex, the outermost layer, said Joseph Lonstein, a professor of neuroscience and psychology at Michigan State University who was not involved in the research. It's "a good first step to understanding much more about whole-brain changes that could be possible in a woman across pregnancy and postpartum," he said.
Animal research has linked some brain changes with qualities that could be helpful when caring for an infant. While the new study doesn’t address the changes in human behavior, Lonstein pointed out that it describes changes in brain areas involved in social cognition or how people interact with others and understand their thoughts and feelings, for example.
The researchers have partners in Spain and are moving forward with the larger Maternal Brain Project, supported by the Ann S. Bowers Women’s Brain Health Initiative and the Chan Zuckerberg Initiative.
Eventually, they hope scientists can use data from a large number of women for things like predicting postpartum depression before it happens.
"There is so much about the neurobiology of pregnancy that we don’t understand yet, and it’s not because women are too complicated. It’s not because pregnancy is some Gordian knot," Jacobs said. "It’s a byproduct of the fact that biomedical sciences have historically ignored women’s health."
