The Syrian regime has been besieging opposition-controlled Douma, preventing main supplies from reaching the city that has recently suffered an electric shortage because of the constant airstrikes.
Last week a similar strike on Douma, which lies east of Damascus in the Ghotta region, killed more than 57 people and left over 100 others injured. Eastern Ghouta has frequently been targeted in deadly airstrikes by al-Assad's forces.
The Observatory also said the death toll from an air raid Friday night on the Bou Kamal city killed 71 people, among them six children.
"There are still many missing under the rubble and most of the injured are in serious condition. Mainly they are civilians," Rami Abdel Rahman, head of the Observatory told dpa.
Abdel Rahman did not say if the raids, which took place in eastern Syria near the border with Iraq, were regime, Russian or US-led counter-terror coalition strikes.
The strikes targeted an area that is mainly controlled by ISIS.
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