US Secretary of State John Kerry, on a visit to Saudi Arabia, sought Saturday to reassure Gulf allies concerned about a perceived warming of ties between Washington and Iran.
He also announced that the Syria Support Group of 20 nations and organisations will meet "very shortly" to help push peace in the war-ravaged country.
Kerry spoke in Riyadh after meeting his Saudi counterpart Adel al-Jubeir and other foreign ministers from the six-nation Gulf Cooperation Council.
"The United States remains concerned about some of the activities that Iran is engaged in in other countries," Kerry told reporters, citing as an example Iran's "support for terrorist groups like Hezbollah" in Lebanon.
Saudi Arabia and its Gulf neighbours perceive a lack of US engagement in the region, particularly in the face of what they see as Iran's "interference" in Yemen, Syria, Lebanon and elsewhere.
Those feelings crystallised with the historic international deal which this month lifted crippling economic sanctions on Iran in return for a scaling back of its nuclear capabilities.
Kerry has long sought to calm concerns among his Gulf allies about the overtures to Iran, the world's leading Shiite power whose relations with Sunni rival Saudi Arabia have worsened this month.
Saudi Arabia and some of its allies cut diplomatic ties with Iran after protesters there burned Riyadh's embassy in Tehran and a consulate in Mashhad city.
The violence broke out after the kingdom executed dissident Saudi Shiite cleric Nimr al-Nimr, a driving force behind anti-government protests.
Nimr was one of four Shiites put to death on January 2 alongside 43 Sunnis. All were convicted of "terrorism".
Jubeir told reporters that he did not see a "coming together" of the US and Iran.
"Iran remains the world's chief sponsor of terrorism," he said, adding that Arab states are ready "to confront" Iran's interference.
"Overall I think the United States is very aware of the danger of Iran's mischief and nefarious activities... I don't believe the United States is under any illusion as to what type of government Iran is," Jubeir added, while Kerry appeared defensive and less at ease than usual.
A senior State Department official earlier told journalists the US understands Saudi anger over the embassy attack but that "lessening tensions is an important objective".
Kerry later met with King Salman and the monarch's son, Deputy Crown Prince Mohammed bin Salman, who is also the defence minister.
He was also to hold talks with Riad Hijab, Riyadh-based general coordinator of Syria's largest opposition coalition.
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