Reigning NBA Most Valuable Player put on a masterclass with 32 points and 11 rebounds as the Denver Nuggets thumped New York Knicks 113-99 on Saturday.
The Nuggets won for just the third time in 10 games – and it wasn't even close.
Second-year big man Zeke Nnaji contributed a career-high 21 points off the bench for a Denver team that never trailed.
It was a third straight defeat for the Knicks, who fell to 5-8 on their home floor at Madison Square Garden.
"I like something here," Jokic said of the historic Manhattan arena – where he exchanged courtside comments with famous Knicks fan Spike Lee. "I don't know what it is."
Jokic connected on 14 of his 19 shots from the floor, including three of seven from 3-point range.
He handed out five assists in just under 27 minutes on court in his third game back since missing four games in late November with a wrist injury.
The Nuggets capitalized on the defensive lapses of the Knicks, pushing their lead to as many as 30 points and connecting on 52% of their shots from the field.
New York, trailing 60-49 at halftime, chipped away at Denver's lead early in the second half, trimming the deficit to six points.
But Denver responded with a 23-3 scoring run and took a 21-point lead into the fourth quarter.
The Knicks, limited to 40% shooting, remained in 11th place in the Eastern Conference, outside the playoff window. The Nuggets, at 11-11, are eighth in the West.
In San Francisco, Derrick White scored 25 points while Dejounte Murray had 22 points and 12 rebounds as the San Antonio Spurs closed the fourth quarter with an 8-1 run to beat the Golden State Warriors 112-107.
Stephen Curry scored 27 points and Jordan Poole added 15 for Golden State, which was playing a night after ending the Phoenix Suns' 18-game winning streak in a marquee Western Conference matchup.
"We didn't panic," White said. "They were up three and we just answered and found a way to win. It's not a good recipe for success. We want to keep the leads that we have, but just stay with it, compete and good things happened tonight.
"We knew they were going to go on a run. They're the Warriors, they've been doing it for years."
Elsewhere, DeMar DeRozan scored 13 of his 29 points in the fourth quarter and Zach LaVine scored a team-high 31 as the Chicago Bulls defeated the Brooklyn Nets 111-107 in New York.
DeRozan made six of 11 shots in the fourth quarter and raised his league-leading total to 178 points in the fourth quarter.
Rookie Ayo Dosunmu and Nikola Vucevic each added 11 points for the Bulls, who shot 47.7% from the floor and made 10 3-pointers.
Kevin Durant finished with 28 points and 10 rebounds for the Nets, who lost for the second time this season to Chicago.
LaMarcus Aldridge added 20 points while James Harden finished with 14 points and 14 assists as the Nets shot 41.4%.
The Nets led 82-79 at the end of the third. Dosunmu made a jump shot with 8:39 left in the fourth quarter to give the Bulls the lead for good at 87-86.
DeRozan scored his final points when he hit a 16-footer for a 103-100 lead with just under three minutes remaining and then assisted on Lonzo Ball's 3-pointer with 17 seconds remaining for a 110-105 edge.
Also, the Milwaukee Bucks took down the Miami Heat 124-102 in Milwaukee. The Bucks won their seventh straight home game and are averaging 115.7 points in those games.