Novak Djokovic, the reigning champion, battled through a grueling five-set thriller against Francisco Cerundolo, ultimately prevailing 6-1, 5-7, 3-6, 7-5, 6-3 to secure his spot in the French Open quarterfinals.
Despite a nagging knee issue, Djokovic's superhuman effort marked his record-breaking 370th Grand Slam victory, surpassing the legendary Roger Federer.
Earlier in the day, women's title contenders Aryna Sabalenka and Elena Rybakina dominated their matches, while 17-year-old Russian Mirra Andreeva extinguished French hopes by defeating Varvara Gracheva.
The Serb also celebrated reaching his 59th major quarterfinal – the most by any men's player – to eclipse his long-time rival Federer again, while an 11th five-sets Roland Garros win tied him with Gael Monfils and Stan Wawrinka in the Open Era.
"Again, a big, big, big thank you because once again, like the last match. The win is your win," an exhausted Djokovic told the crowd in fluent French.
But Djokovic's title rivals in Paris will be smelling blood after another up-and-down display.
The 37-year-old showed no early signs of fatigue from his marathon third-round win over Lorenzo Musetti, a 4-1/2 hour epic that ended in the early hours of Sunday morning, as he blitzed claycourt specialist Cerundolo in the opening set.
He sustained a right knee issue early in the next and needed treatment on court before saving four break points to draw level at 3-3 with a backhand bullet, but allowed his opponent a way back in by surrendering his serve in the 12th game.
Cerundolo grabbed another break early in the next set to go 3-0 up and comfortably got ahead in the clash as alarm bells began to ring for Djokovic in a second straight match at the clay court Grand Slam, which he has won three times.
The finish line seemed to appear in sight for Cerundolo when he raced up 4-2 in the next set, but the 25-year-old squandered the advantage as Djokovic sent down two big serves and produced a spectacular drop en route to holding for 6-5 before leveling the contest.
Having dropped serve after a fast start in the deciding set, Djokovic took a nasty tumble during a point and ranted about the state of the Court Philippe Chatrier surface.
He dusted himself off and the smile returned shortly after as he executed a sensational drop volley while doing the splits at 3-3 and celebrated the point by lying on the court with his arms outstretched in a superhero pose.
With the crowd firmly behind him, Djokovic closed out a superb victory and paid tribute to fans on the main showcourt at around 9 p.m local time.
"I actually felt great coming into the match, as good as I could under the circumstances and played really well first set," Djokovic told reporters.
"Then in the third game of the second set, I slipped, one of the many times that I slipped and fell today. That affected the knee ... At one point I didn't know, to be honest, whether I should continue or not."
Next up for the tournament's top seed is a rematch of last year's final against Norway's Casper Ruud after the seventh seed defeated American Taylor Fritz 7-6(6) 3-6 6-4 6-2.
Alex de Minaur broke a long Australian jinx as the 11th seed battled from a set down to stun Daniil Medvedev 4-6 6-2 6-1 6-3 and become the first man from his nation in two decades to make the last-eight at Roland Garros.
He will face fourth seed Alexander Zverev after the German outlasted 13th seed Holger Rune 4-6 6-1 5-7 7-6(2) 6-2 in a match that ended in early morning hours.
