A Russian submarine on Tuesday fired cruise missiles at Daesh targets in Syria's Deir el-Zour province, the RIA news agency cited Russia's defense ministry as saying.
The submarine, "Veliky Novgorod", launched three "Kalibr" missiles from the eastern Mediterranean, the agency reported.
The Russian defense ministry said the strikes targeted the area around the town of Abu Kamal, one of the few remaining urban strongholds of Daesh in Syria.
The ministry added it could confirm "the destruction of all the given targets." It posted a video on Twitter of a missile blasting out of the sea.
There have been heavy clashes between the Assad regime army and the Daesh terror group in the city of Deir el-Zour in eastern Syria.
Russia said Tuesday that its Veliky Novgorod submarine has carried out four cruise missile strikes on terrorist groups since it was deployed to the Mediterranean in late August.
At Russia's Syrian naval base of Tartus in the eastern Mediterranean, Russian ships have played a prominent role backing up an aerial bombing campaign in support of the Assad regime.
The submarines are covered from Syria by Moscow's S-300 and S-400 missiles systems and its Bastion coastal defense system.
More than 330,000 people have been killed in Syria since the conflict began in March 2011 with anti-government protests.