The Syrian army's air defense system intercepted missiles coming from the direction of Israel that were aimed at targets inside Syria, Assad regime media said on Sunday.
Four cruise missiles were believed to have been launched across the coast through Lebanese airspace towards Syria, a source in the regional alliance supporting Bashar al-Assad told Reuters.
There was also no immediate comment from Israel.
The Britain-based Syrian Observatory for Human Rights, an opposition war monitoring group that has activists around the country, said the missile attack targeted Iranian and Syrian military positions near Damascus.
There were no immediate reports on casualties.
In neighboring Lebanon, Israeli warplanes could be heard flying in the country's airspace at the time of the airstrikes in Syria. Damascus had said in the past that Israeli warplanes have fired missiles into Syria from Lebanon's airspace.
Last month, Israel said it struck dozens of Iranian targets in Syria in a "wide-scale" operation in response to rocket fire on the Israeli-controlled Golan Heights the day before.
Israel has repeatedly struck Iran-linked targets in Syria in recent years and has warned against any permanent Iranian presence on the frontier.
Iran has forces based in Syria, Israel's northern neighbor, and supports Hezbollah militants in Lebanon.