Syrian authorities were forced to reroute flights carrying aid for earthquake victims after an Israeli airstrike knocked Aleppo airport out of service Tuesday, Syrian state media reported.
The Israeli military declined to comment.
Israel has for years been carrying out attacks against what it has described as Iran-linked targets in Syria, where Tehran's influence has grown since it began supporting President Bashar Assad in the civil war that began in 2011.
In the second attack on Aleppo airport in six months, Syrian air defenses intercepted missiles launched from the Mediterranean, west of the coastal city of Latakia, at 2:07 a.m. (2307 GMT), state news agency SANA reported, citing a military source.
The attack caused "material damage" to the airport, SANA cited the source as saying, without mentioning any casualties.
In a statement reported by state media, the transport ministry said humanitarian aid flights would be rerouted to Damascus and Latakia after the "Israeli aggression".
Foreign donors including the United Arab Emirates, Iran, Saudi Arabia and Algeria have flown aid into Aleppo airport since the Feb. 6 earthquake, Syrian state media has reported.
The earthquake killed 1,414 deaths in government-held parts of the country, the government has said.
More than 5,800 were reported killed by the earthquake in the regime and opposition-controlled parts of Syria, according to different sources.
Israel has previously said its airstrikes in Syria have slowed down Iran's entrenchment in the country, where Tehran has supported pro-Assad groups including Lebanon's Hezbollah.
The attack overnight was Israel's third airstrike in Syria this year, according to the Syrian Observatory for Human Rights. Last year, Israel carried out more than 30 airstrikes in Syria, the Observatory said.
In January, the Syrian army said an Israeli missile attack briefly put Damascus airport out of service.
Damascus airport was also struck last year, making it impossible for the United Nations to fly in aid deliveries to needy Syrians for around two weeks, the U.N.'s commission of inquiry said at the time.
Sources told Reuters a rocket attack in Damascus in February, also blamed by Syria on Israel, hit an installation where Iranian officials were meeting to advance programs to develop drone or missile capabilities of Tehran's allies in Syria.
