The powerful chief of staff to Nigerian leader Muhammadu Buhari has died after contracting the novel coronavirus, the presidency said Saturday.

Buhari's office announced in a statement that it "regrets to announce the passage" of Abba Kyari, who acted as a gatekeeper to the president of Africa's most populous nation.

"The deceased had tested positive to the ravaging COVID-19, and had been receiving treatment. But he died on Friday, April 17, 2020," the statement said.

"May God accept his soul."

Kyari, in his seventies, is the highest-profile person in Nigeria to be killed by a virus that has caused 493 confirmed infections, with 17 deaths.

The influential technocrat, who was reported to have suffered from underlying health issues, was seen as one of the dominant figures in the tight-knit group of advisors around Buhari.

He reportedly controlled access to the president, a 77-year old former military ruler now in his second term as democratically elected leader, overseeing key meetings and granting ministerial audiences.

Kyari tested positive for coronavirus in late March after visiting Germany, forcing a string of top Nigerian officials who had been in contact with him to self-isolate.

In a statement released on March 29, Kyari said he had been transferred to Nigeria's biggest city, Lagos, to receive private medical treatment and hoped "to be back at (his) desk very soon."

There has been no official confirmation on whether Buhari has taken a test, but the president has since made repeated televised speeches imposing restrictions to curb the spread of the virus.

The central government has imposed a lockdown on Nigeria's economic hub Lagos and capital Abuja, while state governors have ordered a raft of measures in other regions.

Experts say the country of 200 million is highly vulnerable to the spread of the disease given its weak healthcare system and high population density.