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Turkish vaccine Turkovac receives emergency approval

by DAILY SABAH

ISTANBUL Dec 22, 2021 - 2:21 pm GMT+3
Professor Alper Şener, a member of Turkey's Scientific Advisory Board, holds a bottle containing the Turkovac vaccine, Izmir, Turkey, Nov. 26, 2021. (AA Photo)
Professor Alper Şener, a member of Turkey's Scientific Advisory Board, holds a bottle containing the Turkovac vaccine, Izmir, Turkey, Nov. 26, 2021. (AA Photo)
by DAILY SABAH Dec 22, 2021 2:21 pm
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Turkey’s domestically developed COVID-19 vaccine, Turkovac, has received emergency use approval, Health Minister Fahrettin Koca said Wednesday.

Koca was speaking at the production facility of the vaccine, as he said public hospitals would start using it after approximately 10 days.

The emergency authorization application for the domestically developed COVID-19 vaccine Turkovac was submitted to the Turkish Medicines and Medical Devices Agency (TITCK) last month.

Since early in the vaccine’s development, President Recep Tayyip Erdoğan has vowed to make it available globally, saying it will benefit all.

"Our COVID-19 vaccine Turkovac, which has come to the production and usage stage by receiving the necessary approvals, is a symbol of our efforts to protect our nation against the pandemic in the most effective way," Erdoğan said Tuesday in a video message to the laboratory in southeastern Şanlıurfa province, where the vaccine research and production is being conducted.

Experts say the results of trials are promising and the vaccine, in the form of a booster shot, at least, helps increase antibodies.

Professor Ateş Kara, a member of the Health Ministry’s Coronavirus Scientific Advisory Board, said earlier this month that preliminary data from nationwide trials demonstrated that none of the people vaccinated with Turkovac had severe symptoms of COVID-19 and the vaccine, in addition, rapidly increased antibody levels in the body necessary to fight off the infection when administered as a booster shot.

Kara, who also heads the Turkish Vaccine Institute, told the Anadolu Agency (AA) on Sunday that clinical trial data was rather positive and a comparative study with CoronaVac, an inactive vaccine like Turkovac currently in use in Turkey, also showed promising results.

“No individuals vaccinated with Turkovac had a severe form of COVID-19 requiring hospitalization or intensive care so far. The same applies to a comparative study with CoronaVac. It demonstrates the efficacy of the vaccine. All the data is presented to the committees that are assessing emergency use approval made earlier for Turkovac,” he said.

Turkey is pursuing an ambitious vaccination program against coronavirus, which has claimed more than 78,000 lives in the country since March 2020. The daily number of cases recently dropped below 20,000 while the daily fatalities decreased to below 200. The Health Ministry offers a Pfizer-BioNTech vaccine in addition to CoronaVac to every eligible citizen.

Though the country managed to secure shipments of vaccines sufficient for its population this summer, Turkovac is planning to be administered as booster shots. The Health Ministry already runs a campaign to get more people to volunteer for the vaccine’s trials by presenting it as the third dose to more than 51 million people, who received their two doses of other vaccines.

Kara said they sought to reach about 4,000 people in testing the side effects of Turkovac. “We have an advantage in inactive vaccines. They are more prevalent in the world and have been provided to some 3.5 billion people in the world and we have more data about their side effects and the prevalence of those side effects. Thus, we simply compare them with Turkovac's possible side effects and so far, we had no serious side effects," he said.

Scientists are also running tests for mass production of Turkovac and "stability" tests to determine an expiration date and to see whether the vaccine provides sufficient antigens required for prompting an immune response to the deadly infection. The current expiration date is three months, but it could be extended up to six months based on the results of stability tests and can be further extended up to two years, Kara said.

"We have seen a rapid leap in antibody levels after the booster shots from inactive and messenger RNA (mRNA) vaccines are administered. We now have seen that Turkovac has the same effect in booster shot form," he added.

The inactive vaccine has become the first to reach the Phase 3 trial stage among multiple vaccine projects against coronavirus that are being funded by state agencies. Authorities hope the vaccine will bolster the country’s arsenal in the fight against the pandemic while the government plans to deliver it to countries in need as well once the approval process is completed.

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